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- Title
Antibiotic Metabolites from the Coral-Associated Actinomycete Streptomyces sp. OUCMDZ-1703.
- Authors
Fu, Peng; Kong, Fandong; Wang, Yuanfei; Wang, Yi; Liu, Peipei; Zuo, Guoying; Zhu, Weiming
- Abstract
From the oligotrophic culture of a soft coral-associated actinomycetes strain, Streptomyces sp. OUCMDZ-1703, we isolated and identified two new chlorinated polyketides that we named strepchloritides A and B ( 1 and 2), three thiazole derivatives known as watasemycin A ( 3), pulicatin G ( 4) and aerugine ( 5), along with pyrrole-2-carboxamide, furan-2-carboxamide and 1-(3,5-dihydroxyphenyl)ethanone. The new structures of 1 and 2 were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. The results showed that actinomycete strain OUCMDZ-1703 could use the relative high ratio of chlorine in the oligotrophic medium to synthesize chlorinated natural products. New compounds 1 and 2 displayed cytotoxicity against the MCF-7 cells with IC50 values of 9.9 and 20.2 µmol·L−1, respectively. Thiazole derivatives 3 and 5 were first found to be active against three clinical strains of methicillin-resistant Staphylococcus aureus (MRSA082, MRSA111 and MRSA234) with the same MIC/MBC values of 7.81/7.81 µg·mL−1.
- Publication
Chinese Journal of Chemistry, 2013, Vol 31, Issue 1, p100
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.201201062