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- Title
Absence of HPV Infection Is Associated with Smoker Patients with Squamous Cell Carcinoma of the Oropharynx.
- Authors
Soares, Gláucia Resende; Demathé, Adriana; Mattar, Neivio José; Biasoli, Éder Ricardo; Miyahara, Glauco Issamu
- Abstract
The purpose of this study was to evaluate the survival of patients with SCC of the oropharynx, according to the presence of HPV and tobacco consumption. A total of 37 patients were followed up for at least 5 years after being diagnosed with SCC of the oropharynx. The biopsy tissue was submitted to the polymerase chain reaction (PCR) and in situ hybridization (ISH) methods for broad determination of HPV presence, to identify the presence of high-risk viruses (16 and 18). 12 of the 37 (32.4%) samples were HPV positive, whereas the two specific types of virus were identified in two samples for HPV-16 and in no samples for HPV-18. We observed no significant effect of the virus in survival analysis, irrespective of tobacco consumption. The level of tobacco consumption was significantly higher in the group of HPV-negative patients (P = 0.0283), in which all the patients in this group were smokers. Therefore, HPV did not change the survival of patients with SCC of the oropharynx in this study, indicating that factors other than tobacco need to be studied in conjunction with it, and the level of tobacco consumption is significantly higher in the group of HPV-negative patients.
- Subjects
TRANSMISSION of papillomavirus diseases; SQUAMOUS cell carcinoma; CIGARETTE smokers; OROPHARYNGEAL cancer; TOBACCO use; POLYMERASE chain reaction
- Publication
Journal of Oncology, 2014, p1
- ISSN
1687-8450
- Publication type
Article
- DOI
10.1155/2014/371570