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- Title
CD30+ clonal T-cell lymphoid proliferation of the skin in a patient with hypereosinophilic syndrome.
- Authors
Kempf, Werner; Kazakov, Dmitry V.; Szep, Zoltan; Vanecek, Tomas
- Abstract
We report a hitherto undescribed unusual CD30+ clonal T-cell proliferation in a 46-year-old man with the lymphocytic variant of hypereosinophilic syndrome with a 17-year history of pruritus, generalized persistent papulonodular skin lesions and peripheral blood hypereosinophilia. A skin biopsy showed an eosinophil-rich infiltrate with small to medium-sized CD30+ lymphocytes and Churg-Strauss granulomas. Peripheral blood flow cytometry revealed an aberrant T-cell clone which, molecular genetically, was identical to the T-cell clone detected in the skin. No genetic aberrations of platelet-derived growth factor receptor alpha ( PDGFRA), FIP1L1-PDGFRA, PDGFRB or FGFR1 were found. The skin lesions showed transient response to systemic and topical corticosteroids. The skin lesions represent cutaneous involvement by clonal T-cells in hypereosinophilic syndrome and differ from known cutaneous CD30+ lymphoproliferative disorders.
- Subjects
CELL proliferation; LYMPHOID tissue; HYPEREOSINOPHILIC syndrome; EOSINOPHIL disorders; SKIN diseases; CLINICAL medicine; DISEASES
- Publication
Journal of Cutaneous Pathology, 2015, Vol 42, Issue 2, p130
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.12454