We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis.
- Authors
Cury, Patricia R.; Furuse, Cristiane; de Araújo, Ney S.; de Araújo, Vera C.
- Abstract
Background: The present study evaluates the signal transducer and activator of transcription-3 (STAT-3) expression and activation in actinic cheilitis (AC) and the relationship of this protein with the degree of epithelial dysplasia. Methods: Twenty-five cases of AC were analyzed. Normal lip mucosa was used as a control group. AC lesions were graded as mild, moderate and severe dysplasias. Immunohistochemistry for STAT-3 and phospho-STAT-3 (STAT-3P) was performed using the biotin-streptavidin-peroxidase method, and the sections were evaluated by three blinded examiners. Results: In normal lip mucosa, only cytoplasmic expression of STAT-3 was observed in the basal and parabasal layers. In AC, STAT-3 was expressed in the cell cytoplasm of the epithelial layers, except in the superficial layer. Nuclear expression of STAT-3 in occasional basal and parabasal cells was seen in moderate and severe dysplasias. In normal lip mucosa, nuclear expression of STAT-3P was found throughout the epithelium, except in the superficial layers, and it was more intense in the deeper layers. In AC, STAT-3P was also expressed in all layers, except for the superficial layer. However, in moderate and severe dysplasias, some epithelial cells exhibited loss of STAT-3P expression. Conclusion: In AC, STAT-3 expression depends on the degree of dysplasia, and STAT-3 activation is dysregulated compared with normal tissue.
- Subjects
DYSPLASIA; IMMUNOHISTOCHEMISTRY; CELL transformation; PROTEINS; MUCOUS membranes; HISTOCHEMISTRY
- Publication
Journal of Cutaneous Pathology, 2007, Vol 34, Issue 8, p606
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.2006.00668.x