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- Title
Emerging roles of ferroptosis in liver pathophysiology.
- Authors
Kim, Kyu Min; Cho, Sam Seok; Ki, Sung Hwan
- Abstract
Ferroptosis is a widely recognized process of regulated cell death linking redox state, metabolism, and human health. It is considered a defense mechanism against extensive lipid peroxidation, a complex process that may disrupt the membrane integrity, eventually leading to toxic cellular injury. Ferroptosis is controlled by iron, reactive oxygen species, and polyunsaturated fatty acids. Accumulating evidence has addressed that ferroptosis plays an unneglectable role in regulating the development and progression of multiple pathologies of the liver, including hepatocellular carcinoma, liver fibrosis, nonalcoholic steatosis, hepatic ischemia–reperfusion injury, and liver failure. This review may increase our understating of the cellular and molecular mechanisms of liver disease progression and establish the foundation of strategies for pharmacological intervention.
- Publication
Archives of Pharmacal Research, 2020, Vol 43, Issue 10, p985
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-020-01273-8