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- Title
Spatholobus suberectus Dunn. constituents inhibit sortase A and Staphylococcus aureus cell clumping to fibrinogen.
- Authors
Cho, Hyunjoo; Chung, Beomkoo; Kim, Chang-Kwon; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
- Abstract
Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. In Staphylococcus aureus ( S. aureus), deletion of sortase isoform results in a significant reduction in virulence and infection potential. Twenty flavonoids were isolated from the stem of the folk medicinal plant Spatholobus suberectus Dunn. These compounds were tested against S. aureus-derived sortase A (SrtA), a key transpeptidase for bacterial virulence. Among these active flavonoids, 7-hydroxy-6-methoxy-flavanone ( 3) and formononetin ( 10) were identified as compounds with promising SrtA inhibitory activity. These compounds also exhibited inhibitory activity against S. aureus cell clumping to fibrinogen. The suppression of cell-clumping activity indicates the potential of these compounds in the treatment of S. aureus infections via the inhibition of SrtA.
- Publication
Archives of Pharmacal Research, 2017, Vol 40, Issue 4, p518
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-016-0884-8