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- Title
Time course and clinical characterization of cisplatin‐induced ototoxicity after treatment for nasopharyngeal carcinoma in a South East Asian population.
- Authors
Chan, Sze Ling; Ng, Li Shia; Goh, Xueying; Siow, Chor Hiang; Goh, Han Lee; Goh, Boon Cher; Cheo, Timothy; Loh, Kwok Seng; Brunham, Liam R.
- Abstract
Abstract: Background: The purpose of this study was to characterize the clinical course of hearing loss in patients with nasopharyngeal carcinoma (NPC) and the clinical factors affecting its severity. Methods: The time course of hearing loss in patients with NPC was assessed using threshold shift from baseline and Common Terminology Criteria for Adverse Events (CTCAE) grade. Results: In the chemoradiotherapy (CRT) groups, the threshold shift was significantly higher from 3 months at 4 kHz (P = 2.30 × 10−9, concurrent CRT only) but not within 2 years posttreatment in the radiotherapy (RT) group. The CRT groups had worse CTCAE grades than the RT group (percentage of latest CTCAE grade ≥1: 64.9% vs 29.0%, respectively). Cumulative cisplatin dose and cochlear RT dose significantly affects threshold shifts, especially at high frequencies. Conclusion: Although cisplatin led to high frequency hearing impairment from about 3 months posttreatment, RT conferred no significant hearing impairment in the first 2 years.
- Subjects
OTOTOXICITY; CISPLATIN; NASOPHARYNX cancer patients; CARCINOMA; DEAFNESS; THRESHOLD (Perception); CHEMORADIOTHERAPY; RADIOTHERAPY
- Publication
Head & Neck, 2018, Vol 40, Issue 7, p1425
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25112