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- Title
Multi-agent concurrent chemoradiotherapy for locally advanced head and neck squamous cell cancer in the elderly.
- Authors
Michal, Stephanie A.; Adelstein, David J.; Rybicki, Lisa A.; Rodriguez, Cristina P.; Saxton, Jerrold P.; Wood, Benjamin G.; Scharpf, Joseph; Ives, Denise I.
- Abstract
Background The reported decreasing benefit with increasing age from concurrent chemoradiotherapy in head and neck cancer patients prompted this retrospective review. Methods Two courses of cisplatin-based concurrent chemoradiotherapy were given to fit patients ≥70 years with locoregionally advanced cancers. Clinical characteristics, treatment, and outcomes were compared with those for an identically treated cohort <70 years. Results There were 44 patients ≥70 and 137 patients <70 years. Clinical characteristics, treatment and toxicities were similar except that the elderly were less likely to receive both chemotherapy courses, experienced more myelosuppression, required more unplanned hospitalization, and were feeding-tube dependent longer. Projected 5-year disease-specific survival (71% vs 74%) and freedom from recurrence (69% v. 71%) were nearly identical. Conclusions Although these selected elderly patients experienced greater myelosuppression and supportive care requirements, outcomes were the same as in younger patients. Age alone should not be considered a contraindication to aggressive chemoradiotherapy for this disease. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
- Subjects
RADIOTHERAPY; HEAD &; neck cancer; SQUAMOUS cell carcinoma; DRUG therapy; TREATMENT of diseases in older people
- Publication
Head & Neck, 2012, Vol 34, Issue 8, p1147
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21891