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- Title
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.
- Authors
Magno, Lorenza; Bunney, Tom D.; Mead, Emma; Svensson, Fredrik; Bictash, Magda N.
- Abstract
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to function) has lagged behind. That is now beginning to change, as exemplified by a number of recent exciting and important reports that provide insight into the function of two key gene products – TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) and PLCγ2 (Phospholipase C gamma2) – in microglia, and their role in neurodegenerative disorders. In this review we explore and discuss these recent advances and the opportunities that they may provide for the development of new therapies.
- Subjects
CELL physiology; PHOSPHOLIPASE C; CELL communication; MICROGLIA; GENES; NEURODEGENERATION
- Publication
Molecular Neurodegeneration, 2021, Vol 16, Issue 1, p1
- ISSN
1750-1326
- Publication type
Article
- DOI
10.1186/s13024-021-00436-5