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- Title
POLYETHERURETHANE MEMBRANES MODIFIED WITH RENEWABLE RESOURCE AS A POTENTIAL CANDIDATE FOR BIOMEDICAL APPLICATIONS.
- Authors
Vlad, S.; Butnaru, M.; Filip, D.; Macocinschi, D.; Nistor, A.; Gradinaru, L. M.; Ciobanu, C.
- Abstract
A series of polyetherurethanes (PEU) based on polytetramethylene ether glycol (PTMEG), methylene diphenyl diisocyanate (MDI) and butanediol (BD) modified with diverse proportion of hydroxypropyl cellulose (HPC) was synthesized by solution prepolymer method. The molar ratio of polyether: diisocyanate: chain extender was of 1:4:3, which produces a molar concentration in urethane groups about of 3∙10-3 mole/g. To improve the wetting properties, the PEU matrix was filled with different amount of HPC and then examined by contact angles measurements and dynamic vapour sorption (DVS). The structure of these materials was confirmed by Fourier Transform Infrared (FTIR) spectroscopy and the morphological aspects of these membranes were studied by Scanning Electron Microscope (SEM) analysis. Fibrinogen adsorption and clot weight on these polyurethanes with different HPC content (0-10 wt %) were also investigated. The clot weight, after the triggering coagulation, was determined through recalcification with CaCl2. These preliminary results suggest that this PEU with HPC might be better devices than traditional biodegradable polyurethanes for tissue engineering due to its better blood compatibility.
- Subjects
URETHANE; ETHYLENE glycol; POLYMERS; CONTACT angle; FOURIER transform infrared spectroscopy; SCANNING electron microscopy; BLOOD coagulation; TISSUE engineering
- Publication
Digest Journal of Nanomaterials & Biostructures (DJNB), 2010, Vol 5, Issue 4, p1089
- ISSN
1842-3582
- Publication type
Article