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- Title
Quadrivalent Human Papillomavirus (HPV) Vaccine Induces HPV-Specific Antibodies in the Oral Cavity: Results From the Mid-Adult Male Vaccine Trial.
- Authors
Pinto, Ligia A.; Kemp, Troy J.; Torres, B. Nelson; Isaacs-Soriano, Kimberly; Ingles, Donna; Abrahamsen, Martha; Yuanji Pan; Lazcano-Ponce, Eduardo; Salmeron, Jorge; Giuliano, Anna R.; Pan, Yuanji
- Abstract
<bold>Background: </bold>Human papillomavirus virus type 16 (HPV-16) and HPV-18 cause a large proportion of oropharyngeal cancers, which are increasing in incidence among males, and vaccine efficacy against oral HPV infections in men has not been previously evaluated.<bold>Methods: </bold>Sera and saliva collected in mouthwash and Merocel sponges at day 1 and month 7 were obtained from 150 men aged 27-45 years from Tampa, Florida, and Cuernavaca, Mexico, who received Gardasil at day 1 and months 2 and 6. Specimens were tested for anti-HPV-16 and anti-HPV-18 immunoglobulin G (IgG) levels by an L1 virus-like particle-based enzyme-linked immunosorbent assay.<bold>Results: </bold>All participants developed detectable serum anti-HPV-16 and anti-HPV-18 antibodies, and most had detectable antibodies in both oral specimen types at month 7 (HPV-16 was detected in 93.2% of mouthwash specimens and 95.7% of sponge specimens; HPV-18 was detected in 72.1% and 65.5%, respectively). Antibody concentrations in saliva were approximately 3 logs lower than in serum. HPV-16- and HPV-18-specific antibody levels, normalized to total IgG levels, in both oral specimen types at month 7 were significantly correlated with serum levels (for HPV-16, ρ was 0.90 for mouthwash specimens and 0.92 for sponge specimens; for HPV-18, ρ was 0.89 and 0.86, respectively).<bold>Conclusions: </bold>This is the first study demonstrating that vaccination of males with Gardasil induces HPV antibody levels at the oral cavity that correlate with circulating levels.
- Subjects
FLORIDA; MEXICO; HUMAN papillomavirus vaccines; VIRAL vaccines; GARDASIL (Drug); PAPILLOMAVIRUSES; HEAD &; neck cancer; ENZYME-linked immunosorbent assay; PAPILLOMAVIRUS disease prevention; CLINICAL trials; IMMUNIZATION; IMMUNOGLOBULINS; MOUTH; PAPILLOMAVIRUS diseases; RESEARCH funding; SALIVA; VIRAL antibodies
- Publication
Journal of Infectious Diseases, 2016, Vol 214, Issue 8, p1276
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw359