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- Title
Elevated lipoprotein(a) and lipoprotein-associated phospholipase A<sub>2</sub> are associated with unfavorable functional outcomes in patients with ischemic stroke.
- Authors
Jiang, Xue; Xu, Jie; Hao, Xiwa; Xue, Jing; Li, Ke; Jin, Aoming; Lin, Jinxi; Meng, Xia; Zheng, Lemin; Wang, Yongjun
- Abstract
<bold>Background: </bold>The association of lipoprotein(a) [Lp(a)] and stroke functional outcomes was conflicting. The aim of the study was to clarify whether high Lp(a) is associated with unfavorable functional outcomes in patients with ischemic stroke.<bold>Methods: </bold>A total of 9709 individuals from the third China National Stroke Registry cohort were recruited. Plasma level of Lp(a) at admission was measured with enzyme-linked immunosorbent assay. The cut-off was set at the median for Lp(a). Functional outcome was assessed using the modified Rankin scale (mRS) at 3 months and 1 year after ischemic stroke. The association between Lp(a) and functional outcomes was evaluated using a logistic regression model.<bold>Results: </bold>The median age was 63.0 years, and 31.1% participants were women. Patients in higher Lp(a) group had higher incidences of unfavorable functional outcomes at 3 months. In logistic regression model, elevated Lp(a) levels were associated with unfavorable functional outcomes at 3 months (Q4 vs. Q1: odds ratio 1.33, 95% confidence interval 1.11-1.61). Subgroup analysis showed that in the lower Lp-PLA2 group, Lp(a) level was not associated with functional outcomes, but in the higher Lp-PLA2 group, Lp(a) level was significantly associated with functional outcomes. After grouped by different levels of Lp(a) and Lp-PLA2, the Lp(a) high/ Lp-PLA2 high group showed the highest incidence of unfavorable functional outcomes at 3 months and 1 year.<bold>Conclusions: </bold>Elevated Lp(a) level is associated with unfavorable functional outcomes in patients with ischemic stroke. The increment in both Lp(a) and Lp-PLA2 are associated with unfavorable functional outcomes at 3 months and 1 year after ischemic stroke.
- Subjects
ISCHEMIC stroke; FUNCTIONAL status; ENZYME-linked immunosorbent assay; STROKE patients; TREATMENT effectiveness
- Publication
Journal of Neuroinflammation, 2021, Vol 18, Issue 1, p1
- ISSN
1742-2094
- Publication type
journal article
- DOI
10.1186/s12974-021-02359-w