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- Title
Unmasking bipolarity in recurrent depressive disorder following herpes simplex virus triggered n-methyl-D-aspartate encephalitis.
- Authors
Narasimhappa, Karthik; Mamtani, Harkishan; Jain, Kshiteeja; Holla, Vikram V.; Ganjekar, Sundarnag; Manjunath, Netravathi; Kulanthaivelu, Karthik; Desai, Geetha
- Abstract
Objective: Herpes simplex virus (HSV) infection triggered n-methyl-D-aspartate (NMDA) encephalitis can lead to varied neuropsychiatric manifestations, including movement disorders and manic symptoms. HSV is known to affect the same brain regions as in secondary mania. Method: We present a 35-year-old female diagnosed with recurrent depressive disorder (RDD) who developed NMDA encephalitis triggered by HSV infection. Result: HSV-triggered NMDA encephalitis led to a manic switch in a woman with RDD on antidepressants, along with the new onset of dyskinetic movements. Conclusion: A neurological insult predisposed our patient to the variable effects of antidepressant drugs.
- Subjects
HERPES simplex virus; MENTAL depression; ENCEPHALITIS; MANIA; METHYL aspartate; VIRAL encephalitis
- Publication
Bipolar Disorders, 2024, Vol 26, Issue 2, p192
- ISSN
1398-5647
- Publication type
Article
- DOI
10.1111/bdi.13393