We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report.
- Authors
Inaba, Hidefumi; Ariyasu, Hiroyuki; Iwakura, Hiroshi; Kurimoto, Chiaki; Ueda, Yoko; Uraki, Shinsuke; Takeshima, Ken; Furukawa, Yasushi; Morita, Shuhei; Nakayama, Yoshiaki; Ohashi, Takuya; Ito, Hidefumi; Nishimura, Yoshiharu; Akamizu, Takashi
- Abstract
Background: Autoimmune polyglandular syndrome type 2 (APS-2) is a rare and complex clinical entity, and little is known about its etiology and progression. Case presentation: A 52-year-old woman with autoimmune hepatitis (AIH) and bronchial asthma was diagnosed with APS-2; autoimmune Addison's disease (AD), and Hashimoto's thyroiditis (HT), and she underwent prednisolone (PSL) treatment. Five months later, she presented ptosis and was diagnosed with thymoma-associated myasthenia gravis (MG). Thymectomy and PSL treatment with immuno-suppressants appeared to ameliorate MG, AD, AIH, HT, and bronchial asthma. HLA typing analysis revealed that the patient had susceptible HLA alleles to MG, AIH, and HT in a Japanese population. Conclusions: This case suggests common endocrinological and autoimmune aspects of APS-2 and AIH with thymoma-associated MG, which are considered to be extremely rare complications.
- Subjects
ASTHMA diagnosis; ASTHMA prevention; AUTOIMMUNE disease prevention; ADDISON'S disease; AUTOIMMUNE diseases; AUTOIMMUNE thyroiditis; THORACIC surgery; CHRONIC active hepatitis; IMMUNOSUPPRESSIVE agents; MYASTHENIA gravis; DISEASE progression; THYMOMA; PREDNISOLONE; DISEASE complications
- Publication
BMC Endocrine Disorders, 2020, Vol 20, Issue 1, p1
- ISSN
1472-6823
- Publication type
Article
- DOI
10.1186/s12902-020-0498-5