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- Title
Fluorescent-based micellar incorporated hydrogel materials for selective determination of long-chain aldehydes.
- Authors
Pranee, Piyanan; Kongwutthivech, Jaturong; Chaicham, Chiraporn; Pudhom, Khanitha; Tuntulani, Thawatchai; Tomapatanaget, Boosayarat
- Abstract
A highly sensitive micelle-induced sensory has been developed for detection of long-chain aldehydes as potential biomarkers of respiratory cancers. The micelle-like sensor was fabricated through the partial self-assembly of CTAB and S2 surfactants, containing a fluorescent hydrazine-functionalized dye (Naph-NH2). In principle, long-chain aldehydes with amphiphilic character act as the induced-fit surfactants to form well-entrapped micellar particles, as well as react with Naph-NH2 to form hydrazone derivatives resulting in fluorescent enhancement. The limit of detection (LOD) of micellar Naph-NH2/CTAB/S2 platform was calculated to be ∼ 64.09–80.98 µM for detection of long-chain aldehydes, which showed fluorescent imaging in lung cancer cells (A549). This micellar sensory probe demonstrated practical applicability for long-chain aldehyde sensing in human blood samples with an accepted percent recovery of ~ 94.02–102.4%. Beyond Naph-NH2/CTAB/S2 sensor, the milcellar hybrid sensor was successfully developed by incorporating a micelle-like platform with supramolecular gel regarding to carboxylate-based gelators (Gel1), which showed a tenfold improvement in sensitivity. Expectedly, the determination of long-chain aldehydes through these sensing platforms holds significant promise for point-of-care cancer diagnosis and therapy.
- Subjects
ALDEHYDES; HYDRAZONE derivatives; FLUORESCENT dyes; DETECTION limit; TUMOR markers; HYDRAZONES
- Publication
Microchimica Acta, 2024, Vol 191, Issue 7, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-024-06433-x