We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In vitro osteogenic activities of sulfated derivative of polysaccharide extracted from Tamarindus indica L.
- Authors
Nguyen, Minh Thi Hong; Tran, Chien Van; Nguyen, Phuong Hong; Tran, Quang De; Kim, Min-Sung; Jung, Won-Kyo; Nguyen, Phuong Thi Mai
- Abstract
Osteoporosis, one of the most serious public health concerns caused by an imbalance between bone resorption and bone formation, has a major impact on the population. Therefore, finding the effective osteogenic compounds for the treatment of osteoporosis is a promising research approach. In our study, tamarind (Tamarindus indica L.) seed polysaccharide (TSP) extracted from tamarind seed was subjected to synthesize its sulfate derivatives. The 1H NMR, FT-IR, SEM, monosaccharide compositions and elemental analysis data revealed that tamarind seed polysaccharide sulfate (TSPS) was successfully prepared. As the result, TSPS showed potent effects on inducing osteoblast differentiation via increasing alkaline phosphatase (ALP) activity up to 20% after 10 days and bone mineralization approximately 58% after four weeks at concentration of 20 μg/mL, whereas no statistically increase for both ALP activity and bone mineralization was observed in TSP treatment. Furthermore, TSPS enhanced expression of several marker genes in bone formation. Overall, the obtained data provided novelty on osteogenic compounds originated from TSP of T. indica, as well as scientific fundamentals on drug development and bone tissue engineering for the treatment of osteoporosis and other bone-related diseases.
- Subjects
BONE growth; ALKALINE phosphatase; ELEMENTAL analysis; BONE resorption; PUBLIC health; TISSUE engineering
- Publication
Biological Chemistry, 2021, Vol 402, Issue 10, p1213
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2021-0200