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- Title
Electrochemical biosensors for measurement of colorectal cancer biomarkers.
- Authors
Zhang, Wenxian; Xiao, Guangchun; Chen, Jun; Wang, Li; Hu, Qiongzheng; Wu, Jian; Zhang, Wenhong; Song, Ming; Qiao, Jinwei; Xu, Chonghai
- Abstract
Colorectal cancer (CRC) is associated with one of the highest rates of mortality among cancers worldwide. The early detection and management of CRC is imperative. Biomarkers play an important role in CRC screening tests, CRC treatment, and prognosis and clinical management; thus rapid and sensitive detection of biomarkers is helpful for early detection of CRC. In recent years, electrochemical biosensors for detecting CRC biomarkers have been widely investigated. In this review, different electrochemical detection methods for CRC biomarkers including immunosensors, aptasensors, and genosensors are summarized. Further, representative examples are provided that demonstrate the advantages of electrochemical sensors modified by various nanomaterials. Finally, the limitations and prospects of biomarkers and electrochemical sensors in detection are also discussed.
- Subjects
COLORECTAL cancer; BIOMARKERS; BIOSENSORS; DEATH rate; PROGNOSIS; CANCER-related mortality; ELECTROCHEMICAL sensors
- Publication
Analytical & Bioanalytical Chemistry, 2021, Vol 413, Issue 9, p2407
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-021-03197-8