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- Title
Systematic localization of oct-3/4 to the gastrulating mouse conceptus suggests manifold roles in mammalian development.
- Authors
Downs, Karen M.
- Abstract
Oct-3/4 was localized to the mouse conceptus between the onset of gastrulation and 16-somite pairs (-s; ∼6.5-9.25 days postcoitum, dpc). Results revealed Oct-3/4 in a continuum of morphologically distinct epiblast-derived embryonic and extraembryonic tissues. In the allantois, distal-to-proximal diminution in the Oct-3/4 domain over time and co-localization with Flk-1 in angioblasts accorded with a role in vascular differentiation and the presence of a stem cell reservoir. In addition, visceral endoderm exhibited a dynamic salt-and-pepper distribution, which, combined with previous results of fate mapping and gene expression, suggested that Oct-3/4 is involved in the genesis of definitive endoderm. By 8-s, Oct-3/4 was globally down regulated in all but putative primordial germ cells (PGCs) and some allantoic cell clusters. Taken together, Oct-3/4's expression profile suggests unexpected and potentially far more versatile roles in development than have been previously appreciated. Developmental Dynamics 237:464-475, 2008. © 2008 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2008, Vol 237, Issue 2, p464
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.21438