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- Title
Immobilization of zirconium-glycerolate nanowires on magnetic nanoparticles for extraction of urinary ribonucleosides.
- Authors
Jing Xu; Zheng Zhang; Xiao-Mei He; Ren-Qi Wang; Hussain, Dilshad; Yu-Qi Feng
- Abstract
The authors have immobilized nanowires made from zirconium glycerolate (ZrGly) on magnetite (Fe3O4) nanoparticles by applying a solvothermal growth process using metal-glycerolate as a precursor. The structure and the dissolutionrecrystallization mechanism of the resulting Fe3O4@ZrGly composite were investigated by attenuated total reflection-FTIR, energy-dispersive X-ray analysis, thermogravimetric analysis and solid-state cross polarization/magic angle spinning 13C NMR spectroscopy. The interaction between the zirconium glycerolate in Fe3O4@ZrGly and cis-diols leads to efficient adsorption of riboncleosides which then can be quantified by HPLC with UV detection. The sorbent was successfully applied to the selective enrichment of adenosine, cytidine, uridine and guanosine from spiked human urine samples. The detection limit of the method is in the range from 1.7 to 19 ng⋅mL-1 of nucleosides in spiked human urine, with relative standard deviations of lower than 12.4% and recoveries ranging from 90.6 to 113%.
- Subjects
MAGIC angle spinning; RIBONUCLEOSIDES; MAGNETIC nanoparticles; NANOWIRES; NUCLEAR magnetic resonance spectroscopy; MAGNETITE; NUCLEOSIDES; URIDINE
- Publication
Microchimica Acta, 2018, Vol 185, Issue 1, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-017-2596-2