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- Title
Synthesis of Pyrimidino Derivatives: Potent Antimicrobial Candidates.
- Authors
Chauhan, R.; Siddiqi, A.; Dwivedi, J.
- Abstract
A series of pyimidino derivatives including 4,5-dihydro-5-(1H-indol-1-yl)-6-(phenyl)-4-(4-substituted phenyl) pyrimidine-2-(1H)-one/thione and 4,5-dihydro-4-(3,4,5-trimethoxyphenyl)-6-phenyl-5-[3-(substitute-1-yl))-1H-indol-1-yl]pyrimidin-2(1H)-one/thione have been synthesis and their antimicrobial activity has been assessed in order to study the antimicrobial synergism of indole and benzene nuclei in single molecule. The structures of synthesized compounds were confirmed by IR, NMR and mass spectroscopy data. Antimicrobial activity assessment gives comparable to excellent results against all test microbes. It is concluded that nuclei separately possessing antimicrobial activity exhibit synergism when combined in a single molecule.
- Subjects
PYRIMIDINE derivatives; ANTI-infective agents; NUCLEAR magnetic resonance; ANTIBACTERIAL agents; DRUG synergism
- Publication
Pharmaceutical Chemistry Journal, 2017, Vol 50, Issue 10, p678
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-017-1511-9