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- Title
YABAN MERSİNİ YAPRAĞININ (MYRTUS COMMUNIS L.) SIÇANLARDA DENEYSEL BÖBREK TAŞI HASARINA KARŞI KORUYUCU ETKİSİ.
- Authors
YILMAZ, Halil
- Abstract
The aim of this study is to investigate the protection effect of (70%) extract Myrtuscommunis(MC) leaves extract (300 mg/kg) against the kidney stone modelling created by (0.75%) ethylene glycol (EG). 28 Sprague Dawley male rats, 10 weeks old, were divided into four groups (n=7) as the control group, EG, MC group and protective (EG+MC) group. While 0.75% EG was added to drinking water for 28 days to form a kidney stone model, 300 mg/kg by MC extract was given by gavage to test its protective effect. 24-hour urine samples were collected for calcium, creatinine, uric acid, magnesium, citrate and oxalate. On the 28th day, the rats were sacrificed. Kidney tissues, urine and serum parameters were examined. Kidney tissues were evaluated by hematoxylin eosin (HE) and Pizzolata's (PZ) staining techniques. Tubular dilatation, cellular atrophy and kidney stones were observed in the kidneys of rats in the EG group, while calcium, oxalate, uric acid levels increased, citrate and magnesium values decreased in their urine. Calcium and magnesium levels increased in serum parameters of rats in EG group. The urine and serum values and kidney tissue appearance of rats in EG+MC group were determined closer to the control group. Myrtuscommunisextract has a protective effect against EG-induced kidney stone modeling.
- Subjects
MYRTLE (Plants); KIDNEY stones; PLANT extracts; TREATMENT of calculi; OXALATES
- Publication
Journal of Health Sciences / Sağlık Bilimleri Dergisi, 2021, Vol 30, Issue 1, p17
- ISSN
1018-3655
- Publication type
Article