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- Title
Placental Findings in Singleton Stillbirths: A Case-control Study.
- Authors
Ananthan, Anitha; Nanavati, Ruchi; Sathe, Pragati; Balasubramanian, Haribalakrishna
- Abstract
<bold>Aims: </bold>This prospective observational study compared placental lesions of stillbirth cases and live birth controls, and aimed to determine the cause of stillbirth.<bold>Methods: </bold>The study enrolled 85 stillbirths and 85 live births at the time of delivery.<bold>Results: </bold>There was significantly increased incidence of placental abruption (p = 0.005) and gestational diabetes (p = 0.032) in mothers with stillbirths. Histopathological examination of placenta was significantly abnormal in stillbirths compared with live births (p = 0.004). Delayed villous maturation was significantly more in stillbirths (38.82 vs. 16.47%; p = 0.002). Acute (30.59 vs. 16.47%; p = 0.04) and chronic diffuse villitis (16.47 vs. 4.7%; p = 0.02), chorionic plate acute vasculitis (28.235 vs. 14.11%; p = 0.04) were significantly more in stillbirths. Foetal vascular thrombi in the chorionic plate (30.58 vs. 14.12%; p = 0.02) and avascular villi (24.7 vs. 8.23%; p = 0.006) were significantly more in stillbirths.<bold>Conclusion: </bold>These abnormal placental patterns could provide information about the etiopathogenisis in stillbirths of unknown aetiology.
- Subjects
BIRTH control; GESTATIONAL diabetes; HISTOPATHOLOGY; PLACENTA; VASCULITIS
- Publication
Journal of Tropical Pediatrics, 2019, Vol 65, Issue 1, p21
- ISSN
0142-6338
- Publication type
journal article
- DOI
10.1093/tropej/fmy006