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- Title
Neonatal Mortality in HIV-Exposed Infants Born to Women Receiving Combination Antiretroviral Therapy in Rural Uganda.
- Authors
Ades, Veronica; Mwesigwa, Julia; Natureeba, Paul; Clark, Tamara D.; Plenty, Albert; Charlebois, Edwin; Achan, Jane; Kamya, Moses R.; Havlir, Diane V.; Cohan, Deborah; Ruel, Theodore D.
- Abstract
As human immunodeficiency virus (HIV)-infected women gain access to combination antiretroviral therapy throughout sub-Saharan Africa, a growing number of infants are being born HIV-exposed but uninfected. Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population.
- Subjects
UGANDA; SUB-Saharan Africa; HIV; NEONATAL mortality; HIV-positive children; ANTIRETROVIRAL agents; RURAL geography
- Publication
Journal of Tropical Pediatrics, 2013, Vol 59, Issue 6, p441
- ISSN
0142-6338
- Publication type
Article
- DOI
10.1093/tropej/fmt044