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- Title
flowCL: ontology-based cell population labelling in flow cytometry.
- Authors
Courtot, Mélanie; Meskas, Justin; Diehl, Alexander D.; Droumeva, Radina; Gottardo, Raphael; Jalali, Adrin; Taghiyar, Mohammad Jafar; Maecker, Holden T.; McCoy, J. Philip; Ruttenberg, Alan; Scheuermann, Richard H.; Brinkman, Ryan R.
- Abstract
Motivation: Finding one or more cell populations of interest, such as those correlating to a specific disease, is critical when analysing flow cytometry data. However, labelling of cell populations is not well defined, making it difficult to integrate the output of algorithms to external knowledge sources. Results: We developed flowCL, a software package that performs semantic labelling of cell populations based on their surface markers and applied it to labelling of the Federation of Clinical Immunology Societies Human Immunology Project Consortium lyoplate populations as a use case. Conclusion: By providing automated labelling of cell populations based on their immunophenotype, flowCL allows for unambiguous and reproducible identification of standardized cell types.
- Subjects
CELL populations; CYTOLOGY; GENETICS; FLOW cytometry; CYTOMETRY
- Publication
Bioinformatics, 2015, Vol 31, Issue 8, p1337
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btu807