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- Title
SynaptomeDB: an ontology-based knowledgebase for synaptic genes.
- Authors
Pirooznia, Mehdi; Wang, Tao; Avramopoulos, Dimitrios; Valle, David; Thomas, Gareth; Huganir, Richard L.; Goes, Fernando S.; Potash, James B.; Zandi, Peter P.
- Abstract
Motivation: The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.Results: We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.Availability: http://psychiatry.igm.jhmi.edu/SynaptomeDB/Contact: mpirooz1@jhmi.eduSupplementary information: Supplementary data are available at Bioinformatics online.
- Subjects
ONTOLOGY; PROTEOMICS; BRAIN function localization; NEUROBEHAVIORAL disorders; SYSTEM integration; NEURAL transmission; MEMBRANE proteins; GENETICS; DNA
- Publication
Bioinformatics, 2012, Vol 28, Issue 6, p897
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/bts040