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- Title
Clinical Characteristics and Visual Outcomes of Pediatric Optic Neuritis: A Single Center Experience.
- Authors
Cebeci, Dilek; Gürkaş, Esra; Öztürk, Zeynep; Güven, Alev; Karalök, Zeynep Selen; Değerliyurt, Aydan; Öz, Nefise Arıbaş; Öncel, İbrahim Halil; Özmen, Serkan; Yılmaz, Şükriye; Demirkan, Tülin Hakan
- Abstract
Introduction: The aim of this study was to describe the clinical characteristics, visual outcomes of pediatric patients presenting with first-episode of optic neuritis. Materials and Methods: We reviewed medical records of the patients newly diagnosed with optic neuritis younger than 18 years between January 2014 and December 2018 retrospectively. Results: Twenty-eight patients were included to this study. The mean age at first onset of optic neuritis was 13.2±3.1 (range 6.2-17.3) years. The mean follow-up period was 4.2±3.2 (range 0.6-13.08) years. Seven (25%) patients had recurrent optic neuritis. Optic neuritis involvement was unilateral in 17 (60%) patients. Forty percent of the patients had idiopathic optic neuritis. Of the six patients with demyelinating lesions in cranial magnetic resonance imaging (MRI) at the first admission, three were diagnosed with multiple sclerosis (MS) at the time of first optic neuritis attack, and three were diagnosed within 13.4±4.8 months after the first episode. Eight (38%) of 21 optic neuritis patients had oligoclonal band positivity and the incidence of MS was significantly higher in these patients (p=0.014). The mean visual acuity at nadir was 0.48±0.27 at admission. Whereas it was 0.74±0.31 and 0.76±0.33 at 1 and 6 months respectively. There was a strong correlation between first and sixth-month visual acuity (r=0.98, p=0.001). Conclusion: Our study demonstrated that poor visual acuity (worse than 0.5) at 1 month can predict poor vision at 6 months. The patients with demyelinating lesions in cranial MRI at their first optic neuritis episode, are more likely to develop MS during the follow-up.
- Subjects
OPTIC neuritis; CHILD patients; DISEASE relapse; MAGNETIC resonance imaging; MULTIPLE sclerosis diagnosis; VISUAL acuity
- Publication
Van Tip Dergisi, 2022, Vol 29, Issue 4, p386
- ISSN
1300-2694
- Publication type
Article
- DOI
10.5505/vtd.2022.92604