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- Title
pH-responsive superstructures prepared via the assembly of Fe<sub>3</sub>O<sub>4</sub> amphipathic Janus nanoparticles.
- Authors
Cai, Shuang; Luo, Bin; Zhan, Xiaohui; Zhou, Xiaoxi; Lan, Fang; Yi, Qiangying; Wu, Yao
- Abstract
The strategy of using Fe3O4 amphiphilic Janus nanoparticles (Fe3O4@AJNPs) bearing β-cyclodextrin (β-CD) and aminopyridine (APD) functionalized polymethyl methacrylate (PGMA) to construct pH-stimuli responsive co-assemblies through host-guest interactions between b-CD and APD was proposed. The spherical co-assemblies with an average diameter about 210nm were excellent magnetic responsive and quite stable even up to 2 months in deionized water. The pH-liable capability of these co-assemblies was revealed by disassembly of the formed superstructures with destruction of the built inclusion complexes. The disassembly process was monitored by SEM, TEM, DLS and fluorescent molecules probe. After disassembly of the co-assemblies caused by protonation of nitrogens in APD, hydrophobic PGMA-APD lacking of interactions with the Fe3O4@AJNPs chains was precipitated, and the remained Fe3O4@AJNPs turned to re-assemble to selfassemblies. Besides, the recyclable Fe3O4@APJNs could reassembly with additional PGMA-APD to build co-assemblies with a uniform morphology for several times. These pH-sensitive co-assemblies with high stability, good magnetic responsiveness and cytocompatibility could be used as pH-responsive vehicles within which to encapsulate drugs for subsequent controlled release.
- Subjects
IRON oxides; NANOPARTICLES; CYCLODEXTRINS; AMINOPYRIDINES; POLYMETHYLMETHACRYLATE
- Publication
Regenerative Biomaterials, 2018, Vol 5, Issue 5, p251
- ISSN
2056-3418
- Publication type
Article
- DOI
10.1093/rb/rby016