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- Title
Short- to Mid-Term Results Using Autologous Bone-Marrow Mononuclear Cell Implantation Therapy as a Limb Salvage Procedure in Patients With Severe Peripheral Arterial Disease.
- Authors
Franz, Randall W.; Shah, Kaushal J.; Johnson, Jason D.; Pin, Richard H.; Parks, Alan M.; Hankins, Thomas; Hartman, Jodi F.; Wright, Michelle L.
- Abstract
Short- to mid-term results of a prospective study evaluating dual intramuscular and intra-arterial autologous bone-marrow mononuclear cell (BM-MNC) implantation for the treatment of patients with severe peripheral arterial occlusive disease (PAD) in whom amputation was considered the only viable treatment option are presented. Ankle-brachial indices (ABIs), rest pain, and ulcer healing were assessed at 3 months. Success was defined as improvement in ABI measurements; absence of rest pain; absence of ulcers; and absence of major limb amputations. Twenty patients (21 limbs) have been enrolled. Three-month follow-up evaluation accounting included 18 patients (19 limbs). Four (22.2%) major and 2 (11.1%) minor amputations were performed within 3 months postoperatively. With 17 (94.4%) of 18 limbs demonstrating at least one criterion for success and major amputation avoided in 14 (77.8%) of 18 limbs at the 3-month evaluation, this specific BM-MNC implantation technique is an effective limb salvage strategy for patients with severe PAD.
- Subjects
ISCHEMIA treatment; PERIPHERAL vascular disease treatment; AMPUTATION; ANALYSIS of variance; ANGIOGRAPHY; BONE marrow transplantation; COMPUTER software; CONFIDENCE intervals; FOOT ulcers; LEG; LEG ulcers; LIMB salvage; LONGITUDINAL method; HEALTH outcome assessment; STATISTICS; T-test (Statistics); WOUND healing; DATA analysis; PAIN measurement; TREATMENT effectiveness; ANKLE brachial index
- Publication
Vascular & Endovascular Surgery, 2011, Vol 45, Issue 5, p398
- ISSN
1538-5744
- Publication type
Article
- DOI
10.1177/1538574411405545