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- Title
Response Heterogeneity With Exercise Training and Physical Activity Interventions Among Persons With Multiple Sclerosis.
- Authors
Baird, Jessica F.; Motl, Robert W.
- Abstract
Multiple sclerosis (MS) is a heterogeneous disease, both in its pathology and symptomology. This poses a challenge for the medical management and rehabilitation of MS; however, physical activity and exercise training are rehabilitation approaches that have demonstrated beneficial effects on many of the burdensome consequences of MS such as mobility impairment and fatigue. Given the heterogeneous course of MS, it is possible that outcomes of physical activity and exercise training interventions demonstrate heterogeneity both in the magnitude and pattern of change, but there has been little focus on response heterogeneity with these interventions among persons with MS. In this narrative review, a search of the existing literature was performed to identify studies that reported individual participant data, which was used to describe the variability in the response to physical activity and exercise training interventions among persons with MS. Inter-individual variability seemingly occurs across outcomes and modalities, which underscores the consideration of factors that might influence response heterogeneity. Factors related to MS disease characteristics, nervous system damage, and the degree of MS-related disability might influence individual responsiveness. Large-scale studies that permit the examination of heterogeneity and its predictors will inform future research on the area of physical activity and exercise training in MS, and lead to the development of individually tailored rehabilitation approaches that will more effectively elicit change.
- Subjects
EXERCISE therapy; FATIGUE (Physiology); MOVEMENT disorders; MULTIPLE sclerosis; NEUROLOGICAL disorders; SYMPTOMS; TREATMENT effectiveness; PHYSICAL activity
- Publication
Neurorehabilitation & Neural Repair, 2019, Vol 33, Issue 1, p3
- ISSN
1545-9683
- Publication type
Article
- DOI
10.1177/1545968318818904