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- Title
Reversible posterior leukoencephalopathy syndrome: diagnosis and management in the setting of lung transplantation Tsang et al. RPLS in lung transplantation.
- Authors
Tsang, B. K. T.; Kermeen, F. D.; Hopkins, P. M. A.; Chambers, D. C.
- Abstract
Reversible posterior leukoencephalopathy syndrome (RPLS) is a potentially devastating early complication of calcineurin inhibitor (CNI) therapy in solid organ transplantation. Management centres on cessation of CNI therapy; however, this strategy is complicated in lung transplantation because of the threat of allograft rejection, or, if CNI is replaced with mammalian target of rapamycin-based immunosuppression, poor wound healing and bronchial dehiscence. We describe four cases of RPLS after lung transplantation, emphasizing the diagnostic and management approach required to maintain a healthy allograft and ensure that RPLS is, as the name suggests, reversible.
- Subjects
CALCIUM-binding proteins; LUNG transplantation; HEALTH outcome assessment; CASE studies; TREATMENT effectiveness; RETROSPECTIVE studies; POSTERIOR leukoencephalopathy syndrome; DRUG side effects; PATHOLOGICAL physiology; THERAPEUTICS; DIAGNOSIS
- Publication
Internal Medicine Journal, 2010, Vol 40, Issue 10, p716
- ISSN
1444-0903
- Publication type
Article
- DOI
10.1111/j.1445-5994.2010.02314.x