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- Title
Vardenafil: a Phosphodiesterase-5 Inhibitor with protective action against the development of Multiple Organ Dysfunction Syndrome (MODS).
- Authors
de Oliveira, Granville Garcia; de Oliveira, Samer A. H.; Kots, Alexander; Bian, Ka; Murad, Ferid
- Abstract
Introduction: MODS is a pathology associated to nonspecific and severe trauma, characterized by elevated morbidity and mortality. The intense inflammatory MODS-related reactions generates disseminated micro-thrombi, the most relevant pathophysiologic component in the induction of this syndrome. Nitric oxide concentration elevation has the potential of counteracting the typical systemic vasoconstriction, as well as the platelet-induced hyper-coagulation. A phosphodiesterase 5 inhibitorvardenafil, would, possibly, act protectively by inducing a NO system elevation resulting in diffuse vasodilatation, besides reduction of endothelial lesions and platelet-induced hyper-coagulation, thus, preventing MODS development. Methods: MODS was induced through the micro-neurosurgical bilateral anterior hypothalamic lesions model. Experimental groups of 10 Wistar rats were divided into: a) Non-operated control; b) Operated control group; c) Pre-treated with vardenafil operated group; d) Post-treated with vardenafil operated group. The animals were sacrificed after 24 hours and submitted to histopathologic examination of five organs: brain, lungs, stomach, kidneys and, liver. Results: The anterior hypothalamus stereotaxic electrolytic lesions resulted in a full picture of MODS with disseminated multiple-organs lesions, provoked, primarily, by diffusely spread micro-thrombi. The pretreatment with vardenafil 2 hours before the micro-neurosurgical lesions reduced significantly (p>0.01) the lesions development in 66.37%, as compared to the operated-control. The post-treatment with vardenafil, 2 hours after the micro-neurosurgical lesions, also reduced significantly (p>0.01) the lesions development in 59.64% as compared to the operated control. Conclusion: Vardenafil, in the doses and timing utilized, showed to act as a protective agent against the experimentally-induced MODS.
- Subjects
MULTIPLE organ failure; VARDENAFIL; PHOSPHODIESTERASE inhibitors; INFLAMMATION; PATHOLOGICAL physiology; THERAPEUTICS
- Publication
Revista de Medicina e Saúde de Brasília, 2014, Vol 3, Issue 3, p224
- ISSN
2238-5339
- Publication type
Article