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- Title
Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism.
- Authors
Ozaki, K. S.; Marques, G. M.; Nogueira, E.; Feitoza, R. Q.; Cenedeze, M. A.; Franco, M. F.; Mazzali, M.; Soares, M. P.; Pacheco-Silva, A.; Câmara, N. O. S.
- Abstract
Heme oxygenase-1 (HO-1) has a microsatellite polymorphism based on the number of guanosine-thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post-injury. We correlated HO-1 polymorphism with renal graft function. The HO-1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (<27 repeats) and long repeats (L) (≥27 repeats). A total of 47.5% of the donors carried the S allele. The allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. For the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow-up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN.
- Subjects
HEME oxygenase; KIDNEY transplantation; HOMOGRAFTS; GENETIC polymorphisms; COMPLICATIONS from organ transplantation
- Publication
Clinical Transplantation, 2008, Vol 22, Issue 5, p609
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1111/j.1399-0012.2008.00832.x