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- Title
Regulation of anti-tumor immunity by metal ion in the tumor microenvironment.
- Authors
Yaoxin Gao; Shasha Liu; Yifan Huang; Feng Li; Yi Zhang
- Abstract
Metal ions play an essential role in regulating the functions of immune cells by transmitting intracellular and extracellular signals in tumor microenvironment (TME). Among these immune cells, we focused on the impact of metal ions on T cells because they can recognize and kill cancer cells and play an important role in immune-based cancer treatment. Metal ions are often used in nanomedicines for tumor immunotherapy. In this review, we discuss seven metal ions related to anti-tumor immunity, elucidate their roles in immunotherapy, and provide novel insights into tumor immunotherapy and clinical applications.
- Subjects
IMMUNOREGULATION; METAL ions; TUMOR microenvironment; ION bombardment; T cells
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1379365