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- Title
CD44: a cancer stem cell marker and therapeutic target in leukemia treatment.
- Authors
Shuang Wu; Yicheng Tan; Fanfan Li; Yixiang Han; Shenghui Zhang; Xiaofei Lin
- Abstract
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.
- Subjects
CANCER stem cells; CELL adhesion molecules; CD44 antigen; CELL communication; EXTRACELLULAR matrix
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1354992