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- Title
Human leucocyte antigen- Bw4 and Gag-specific T cell responses are associated with slow disease progression in HIV-1 B-infected anti-retroviral therapy-naive Chinese.
- Authors
Li, W.‐H.; Li, C.‐Y.; Yang, H.‐B.; Zhang, H.‐P.; Zhang, X.; Kong, L.‐S.; Xu, X.‐N.; Lu, S.‐C.; Yan, H.‐P.
- Abstract
In China, the majority of human immunodeficiency virus ( HIV) infections are predominately subtype B. It is important to characterize the HIV-1 subtype B-specific and its T cell response within the Chinese population, with the aim of identifying protective correlates of immunity to control HIV-1 infections. In this study, we performed a comprehensive analysis looking into the magnitude/strength of T cell responses directed at the Gag protein of the HIV-1 subtype B, one of the most conserved HIV-1 proteins. The study group consisted of anti-retroviral native and chronic HIV-1 subtype B-infected individuals. We used enzyme-linked immunospot ( ELISPOT) assay to quantify the total T cell responses to HIV-1 Gag at the single peptide level. Twenty-eight (38%) peptides were recognized in 24 (82·8%) individuals. The p24 was identified as the most frequently recognized subunit protein with the greatest T cell response in the test, which correlated positively with CD4+ T cell count and inversely with viral load ( VL). At the level of the human leucocyte antigen ( HLA) supertypes, we detected the highest levels and a significant correlation with both the CD4+ T cell count and the VL with Gag T cell responses in Bw4/ Bw4. These findings demonstrate that (i) the HIV-1 B Gag p24-specific immune responses play an important role in controlling viral replication and slowing clinical progression; and (ii) HLA- Bw4/ Bw4 allele has stronger T cell responses, which is associated with slow clinical progression in Chinese HIV patients.
- Subjects
LEUCOCYTES; T cells; GAG proteins; DISEASE progression; HIV infections; ANTIRETROVIRAL agents; HLA histocompatibility antigens; CHINESE people; ENZYME-linked immunosorbent assay; DISEASES
- Publication
Clinical & Experimental Immunology, 2013, Vol 171, Issue 3, p298
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/cei.12025