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- Title
Pulmonary blood transit time and impaired arterial oxygenation in patients with chronic liver disease.
- Authors
Katsuta, Yasumi; Honma, Hiroshi; Zhang, Xue-Jun; Ohsuga, Masaru; Komeichi, Hirokazu; Shimizu, Shuji; Katoh, Yoshihito; Miura, Hiroshi; Satomura, Katsuaki; Aramaki, Takumi; Takano, Teruo
- Abstract
Background Contrast-enhanced echocardiography (GEE) using agitated saline can detect intrapulmonary vasodilatation (IPVD) in patients with hepatopulmonary syndrome (HPS). We estimated the pulmonary transit time of erythrocytes (PTT) by GEE, using microbubbles, and studied its relationship to arterial oxygenation in chronic liver disease. Methods. Sixteen patients with chronic liver disease and seven healthy subjects were studied. PTT was defined as the time between opacification of the right atrium and left atrium on GEE, using human serum albumin-air microhubble complexes with a mean diameter of 4 μm (Albunex). 11W!) was detected by GEE with agitated saline. Arterial blood gases were analyzed with patients in the supine position, and while they were seated. Cardiac output (CO) was determined by Doppler echocar-diography. Results. The mean PTT value for all of the patients was 4.0 ± 1.4 s. One of the 3 patients who showed IPVD was normoxemic. Mild orthodeoxia was observed in the patients with abnormal alveolar-arterial oxygen difference (A-a!)02) values (>15 mmHg), hut not in those with normal A-aD02 values, or in the healthy subjects. PTT was correlated with PaO2 (r = 0.52; P< 0.05; n 16) and A-aD02 (r -0.54; P < 0.05; n = 16) in the seated position. CO was significantly correlated with PTT (r -0.62; P < 0.05; n 15), hut not with Pa02 and A-aD02 in both positions. conclusions. PTT may he a useful parameter for evaluating arterial oxygenation in patients with chronic liver disease with early HPS.
- Subjects
ECHOCARDIOGRAPHY; VASODILATION; BLOOD gases; SERUM; SUPINE position; LIVER diseases
- Publication
Journal of Gastroenterology, 2005, Vol 40, Issue 1, p57
- ISSN
0944-1174
- Publication type
Article
- DOI
10.1007/s00535-004-1495-6