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- Title
Flow cytometric assessment of anti-neuronal antibodies in central nervous system involvement of systemic lupus erythematosus and other autoimmune diseases.
- Authors
Kang, E. H.; Shen, G. Q.; Morris, R.; Metzger, A.; Lee, E. Y.; Lee, Y. J.; Lee, E. B.; Song, Y. W.
- Abstract
The objective of this study is to evaluate the association between anti-neuronal antibody (anti-NA) and central nervous system (CNS) manifestations of systemic lupus erythematosus (SLE) and other rheumatic diseases using a flow cytometric method. Anti-NA was measured by flow cytometry in serum and cerebrospinal fluid (CSF) samples from patients with SLE (n =44 for serum, n = 17 for CSF), other rheumatic diseases (n = 64 for serum, n = 21 for CSF) and from healthy controls (n = 65 for serum, n = 18 for CSF). Serum anti-NA was more frequently observed in SLE (31.8%, 14/44) than in other rheumatic diseases (4.7%, 3/64, P < 0.001) or in healthy controls (0%, 0/65, P < 0.00001). In SLE patients, the frequency of serum anti-NA was significantly higher in CNS-SLE (76.5%, 13/17) than in non CNS-SLE (3.7%, 1/27, P < 0.000001). CSF anti-NA was detected in 88.2% (15/17) of CNS-SLE and was more frequently detected in CNS-SLE (15/17, 88.2%) than in other rheumatic diseases with CNS involvement (1/21, 4.8%, P < 0.000001) or in healthy controls (0/18, P < 0.000001). In conclusion, serum anti-NA was more frequently found in CNS-SLE than in non CNS-SLE, other rheumatic diseases or in healthy controls. The frequency of CSF anti-NA in CNS-SLE was significantly higher than in other rheumatic diseases with CNS involvement or in healthy controls.
- Subjects
IMMUNOGLOBULINS; CENTRAL nervous system; SYSTEMIC lupus erythematosus; RHEUMATISM; PATIENTS; FLOW cytometry
- Publication
Lupus, 2008, Vol 17, Issue 1, p21
- ISSN
0961-2033
- Publication type
Article
- DOI
10.1177/0961203307085256