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- Title
Cohort profile: The study of respiratory pathogens in Andean children.
- Authors
Grijalva, Carlos G; Griffin, Marie R; Edwards, Kathryn M; Williams, John V; Gil, Ana I; Verastegui, Héctor; Hartinger, Stella M; Vidal, Jorge E; Klugman, Keith P; Lanata, Claudio F
- Abstract
We investigated respiratory pathogens in a prospective cohort study of young children living in the Peruvian Andes. In the study we assessed viral respiratory infections among young children, and explored interactions of viruses with common respiratory bacteria, especially Streptococcus pneumoniae. Through weekly household visits, data were collected on the signs and symptoms of acute respiratory illness (ARI), nasal samples were collected to test for viruses during episodes of ARI, and nasopharyngeal samples were collected on a monthly basis to monitor bacterial colonisation. We also collected data on vaccination coverage, patterns of social mixing, geographic information, and environmental and socio-demographic variables. Understanding the interaction of respiratory viruses with bacteria and its impact on the burden and severity of ARIs in rural areas of developing countries is critical to designing strategies for preventing such infections.
- Subjects
PERU; INFLUENZA prevention; STREPTOCOCCAL disease prevention; INFLUENZA epidemiology; ANDEANS (South American people); INFLUENZA vaccines; HAEMOPHILUS diseases; STREPTOCOCCAL diseases; RESPIRATORY infections; PNEUMOCOCCAL vaccines; STAPHYLOCOCCAL diseases; HAEMOPHILUS influenzae; STREPTOCOCCUS; STAPHYLOCOCCUS aureus; RESEARCH funding; ACUTE diseases; LONGITUDINAL method
- Publication
International Journal of Epidemiology, 2014, Vol 43, Issue suppl_1, p1021
- ISSN
0300-5771
- Publication type
journal article
- DOI
10.1093/ije/dyt065