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- Title
A Population Pharmacokinetic Model for <sup>51</sup>Cr EDTA to Estimate Renal Function.
- Authors
Kuan, Isabelle; Duffull, Stephen; Putt, Tracey; Schollum, John; Walker, Robert; Wright, Daniel; Kuan, Isabelle H S; Duffull, Stephen B; Putt, Tracey L; Schollum, John B W; Walker, Robert J; Wright, Daniel F B
- Abstract
<bold>Background and Objectives: </bold>51Cr EDTA clearance (CL) from plasma is used to estimate glomerular filtration rate (GFR). We propose that current methods for analysing the raw 51Cr EDTA measurements over-simplifies the disposition of 51Cr EDTA and therefore could produce biased GFR estimates. The aim of this study was to develop a population pharmacokinetic model for 51Cr EDTA disposition and to compare model-predicted GFR to other methods of estimating renal function.<bold>Patients and Methods: </bold>Data from 40 individuals who received ~7.4 MBq of 51Cr EDTA, as an intravenous bolus, were available for analysis. Plasma radioactivity (counts/min) was measured from timed collection points at 2, 4, 6 and 24 h after the dose. A population analysis was conducted using NONMEM® version 7.2. Model-predicted GFR was compared with other methods for estimating renal function using mean prediction error (MPE).<bold>Results: </bold>A two-compartment pharmacokinetic model with first-order elimination best fit the data. Compared with the model predictions, creatinine CL from 24 h urine data was unbiased. The commonly used 'slope-intercept' method for estimating isotopic GFR was positively biased compared with the model (MPE 15.5 mL/min/1.73 m2 [95% confidence interval {CI} 8.9-22.2]. The Cockcroft Gault, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) equations led to negatively biased GFR estimates (MPE -19.0 [95% CI -25.4 to -12.7], -20.1 [95% CI -27.2 to -13.1] and -16.5 [95% CI -22.2 to -10.1] mL/min/1.73 m2, respectively).<bold>Conclusions: </bold>The biased GFR estimates were most obvious in patients with relatively normal renal function. This may lead to inaccurate dosing in patients who are receiving drugs with a narrow therapeutic range where dosing is adjusted according to GFR estimates (e.g. carboplatin).<bold>Study Registration: </bold>The study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), number: ACTRN 12611000035921.
- Subjects
PHARMACOKINETICS; GLOMERULAR filtration rate; KIDNEY disease diagnosis; RADIOACTIVITY; CLINICAL trials; KIDNEY physiology; BIOLOGICAL models; COMPARATIVE studies; ETHYLENEDIAMINETETRAACETIC acid; KIDNEY diseases; RESEARCH methodology; MEDICAL cooperation; RADIOISOTOPES; RESEARCH; EVALUATION research; RANDOMIZED controlled trials
- Publication
Clinical Pharmacokinetics, 2017, Vol 56, Issue 6, p671
- ISSN
0312-5963
- Publication type
journal article
- DOI
10.1007/s40262-016-0489-x