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- Title
Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway.
- Authors
Wang, Xi; Shao, Gang; Hong, Xiangyu; Shi, Yue; Zheng, Yiting; Yu, Yucheng; Fu, Caiyun
- Abstract
Colon cancer is one of the most common digestive tract malignancies, having the second highest mortality rate among all tumors, with a five-year survival of advanced patients of only 10%. Efficient, targeted drugs are still lacking in treating colon cancer, so it is urgent to explore novel druggable targets. Here, we demonstrated that annexin A1 (ANXA1) was overexpressed in tumors of 50% of colon cancer patients, and ANXA1 overexpression was significantly negatively correlated with the poor prognosis of colon cancer. ANXA1 promoted the abnormal proliferation of colon cancer cells in vitro and in vivo by regulating the cell cycle, while the knockdown of ANXA1 almost totally inhibited the growth of colon cancer cells in vivo. Furthermore, ANXA1 antagonized the autophagic death of honokiol in colon cancer cells via stabilizing mitochondrial reactive oxygen species. Based on these results, we speculated that ANXA1 might be a druggable target to control colon cancer and overcome drug resistance.
- Subjects
COLON cancer; ANNEXINS; DRUG resistance in cancer cells; COLON cancer prognosis; CANCER cell proliferation; REACTIVE oxygen species
- Publication
Pharmaceuticals (14248247), 2023, Vol 16, Issue 1, p70
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph16010070