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- Title
Aberrant Wnt Signaling in Leukemia.
- Authors
Staal, Frank J. T.; Famili, Farbod; Perez, Laura Garcia; Pike-Overzet, Karin
- Abstract
The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment.
- Subjects
HEMATOPOIETIC stem cells; CELLULAR signal transduction; CHRONIC lymphocytic leukemia; HEMATOPOIESIS; HOMEOSTASIS; LEUKEMIA; LYMPHOBLASTIC leukemia; CHRONIC myeloid leukemia; ACUTE myeloid leukemia; NEOPLASTIC cell transformation; METABOLISM; PHYSIOLOGY
- Publication
Cancers, 2016, Vol 8, Issue 9, p78
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers8090078