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- Title
Association of rs2013162 and rs2235375 Polymorphisms in IRF6 Gene with Susceptibility to Non-Syndromic Cleft Lip and Palate.
- Authors
Soleymani, Masoumeh; Ebadifar, Asghar; Khosravi, Maryam; Esmaeilzadeh, Emran; Khorram Khorshid, Hamid Reza
- Abstract
Background: Non-syndromic cleft lip occurs by the interaction of environmental and genetic factors. The purpose of the current study was to analyze the association of Single Nucleotide Polymorphisms (SNPs) in IRF6 and NSCL/P in an Iranian population. Methods: A group of 105 children with NSCL/P and 185 normal controls were included in the current study. Genotyping of IRF6 rs2013162 and rs2235375 was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Results: A substantial association of AA and CA genotypes in rs2013162 with the risk of NSCL/P (AA vs. CC; OR=2.36; 95%CI [1.05-5.29], p=0.004; and CA vs. CC; OR=0.47; 95%CI [0.28-0.79], p=0.018) was found. However, there were no important associations between A allele and risk of NSCL/P (p=0.980). According to logistic regression analysis results, subjects with GG genotype and G allele in rs2235375 polymorphism had increased risk of NSCL/P. Conclusion: The IRF6 polymorphisms are associated with the susceptibility to NSCL/P in Iranian population.
- Subjects
IRAN; CLEFT lip -- Risk factors; CONFIDENCE intervals; SINGLE nucleotide polymorphisms; CLEFT palate; CASE-control method; ALLELES; RISK assessment; GENOTYPES; DESCRIPTIVE statistics; POLYMERASE chain reaction; ODDS ratio; LOGISTIC regression analysis; DISEASE risk factors
- Publication
Avicenna Journal of Medical Biotechnology, 2022, Vol 14, Issue 2, p181
- ISSN
2008-2835
- Publication type
Article
- DOI
10.18502/ajmb.v14i2.8885