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- Title
A Familial Case of Hyper-IgM Immunodeficiency.
- Authors
Iwakiri, Ryuichi; Nakano, Teruaki; Harada, Mine; Nagafuchi, Seiho; Teshima, Takanori; Ono, Noriyuki; Yamamoto, Yusei; Niho, Yoshiyuki
- Abstract
A 22-year-old male was diagnosed as having immunodeficiency with hyper-IgM based upon recurrent pneumonia, marked elevation of serum IgM and markedly decreased level of IgG. IgG- or IgA-bearing B cells were not detected in peripheral blood while a number and a proportion of peripheral blood T lymphocytes were normal. Peripheral blood lymphocytes from this patient proliferated normally in response to T-independent and T-dependent B cell mito-gens, and to T cell mitogens. Furthermore, the same type of dysgammaglobulinemia with increased IgM was found in the patient's father and brother. From these observations, it is suggested that it is a rare case of autosomal dominant or polygenal inheritance of hyper-IgM immunodeficiency. Copyright © 1992 S. Karger AG, Basel
- Publication
Acta Haematologica, 1992, Vol 88, Issue 1, p50
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204596