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- Title
Lymphoid Antigens on Blast Cells in the Agranular Metamorphosis of Chronic Myelogenous Leukaemia.
- Authors
Bacigalupo, A.; Santini, G.; Piaggio, G.; Risso, M.; van Lint, M.T.; Carella, M.; Damasio, E.E.; Raffo, M.C.; Marmont, A.M.
- Abstract
Undifferentiated blasts from a Ph'-positive chronic myelogenous leukaemia (CML) in terminal metamorphosis were reacted in an indirect ímmunofluo-rescence test with antilymphocytic globulins (AHLGs), raised against cultured lymphoblasts, thoracic duct and peripheral blood lymphocytes from healthy donors. After proper myeloid and/or monocytic absorptions the AHLGs interacted strongly with the undifferentiated blasts of CML, while this was not true for parallel controls with non-lymphoid leukaemias, both acute and chronic. The intensity of fluorescence, as determined by the use of a microfluorimeter, on these agranular blasts was comparable to the positivity of lymphoid cells from acute and chronic lymphatic leukaemias. These findings lend further support to the conception of a lymphoblast-like variety of terminal blastic crisis in chronic myelogenous leukaemia. Copyright © 1978 S. Karger AG, Basel
- Publication
Acta Haematologica, 1978, Vol 60, Issue 5, p280
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000207724