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- Title
Complete remission after first-line radio-chemotherapy as predictor of survival in extranodal NK/T cell lymphoma.
- Authors
Chauchet, Adrien; Michallet, Anne-Sophie; Berger, Fran�oise; Bedgedjian, Isabelle; Deconinck, Eric; Sebban, Catherine; Antal, Daciana; Orfeuvre, Hubert; Corront, Bernadette; Petrella, Tony; Hacini, Maya; Bouteloup, Marie; Salles, Gilles; Coiffier, Bertrand
- Abstract
Background: Extranodal nasal-type NK/T-cell lymphoma is a rare and severe disease. Considering the rarity of this lymphoma in Europe, we conducted a multicentric retrospective study on nasal-type NK/T cell lymphoma to determine the optimal induction strategy and identify prognostic factors. Methods: Thirty-six adult patients with nasal-type NK/T-cell lymphoma were recruited and assessed. In total, 80 %of patients were classified as having upper aerodigestive tract NK/T-cell lymphoma (UNKTL) and 20 % extra-upper aerodigestive tract NK/T-cell lymphoma (EUNKTL). Results: For advanced-stage disease, chemotherapy alone (CT) was the primary treatment (84 % vs. 10 % for combined CT + radiation therapy (RT), respectively), while for early-stage disease, 50 % of patients received the combination of CT + RT and 50 % CT alone. Five-year overall survival (OS) and progression-free survival (PFS) rates were 39 % and 33 %. Complete remission (CR) rates were significantly higher when using CT + RT (90 %) versus CT alone (33 %) (p<0.0001). For early-stage disease, CR rates were 37 % for CT alone versus 100 % for CT + RT. Quality of response was significantly associated with survival, with 5-year OS being 80 % for CR patients versus 0 % for progressive disease patients (p<0.01). Conclusion: Early RT concomitantly or sequentially with CT led to improved patient outcomes, with quality of initial response being the most important prognosticator for 5-year OS
- Subjects
EUROPE; T-cell lymphoma; DRUG therapy; RADIOTHERAPY; RETICULOENDOTHELIAL granulomas; LYMPHOCYTES
- Publication
Journal of Hematology & Oncology, 2012, Vol 5, Issue 1, p27
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/1756-8722-5-27