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- Title
Reticulate hyperpigmentation in systemic sclerosis: a case report and review of the literature.
- Authors
Chuamanochan, Mati; Haws, Andrea L.; Pattanaprichakul, Penvadee
- Abstract
<bold>Introduction: </bold>Systemic sclerosis is a systemic connective tissue disease with variable cutaneous presentations. Although pigmentary disturbances have been described in systemic sclerosis, a reticulate hyperpigmentation has only been reported in one case of systemic sclerosis to date.<bold>Case Presentation: </bold>We describe a previously healthy 51-year-old Thai woman who presented with a reticulate hyperpigmentation affecting her trunk and extremities, together with sclerodactyly and proximal sclerosis, resulting in a new diagnosis of systemic sclerosis.<bold>Conclusions: </bold>To date, the pathogenesis of reticulate hyperpigmentation in systemic sclerosis remains unclear. Increased melanin synthesis and altered thermoregulatory mechanism are proposed to be involved in the pathogenesis of this presentation. This case represents an unusual cutaneous feature of reticulate hyperpigmentation in the setting of systemic sclerosis.
- Subjects
THAILAND; SYSTEMIC scleroderma; HYPERPIGMENTATION; CONNECTIVE tissue diseases; MELANOGENESIS; MEDICAL literature reviews; MEDICAL research; DIAGNOSIS; ADRENOCORTICAL hormones; COLCHICINE; COMBINED modality therapy; MEDICAL radiology; SKIN; ULTRAVIOLET radiation; WEIGHT loss; TREATMENT effectiveness; GOUT suppressants; DISEASE complications; THERAPEUTICS
- Publication
Journal of Medical Case Reports, 2015, Vol 9, Issue 1, p1
- ISSN
1752-1947
- Publication type
journal article
- DOI
10.1186/s13256-015-0697-2