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- Title
Human cord blood-derived mononuclear cell transplantation for viral encephalitis-associated cognitive impairment: a case report.
- Authors
Wan-Zhang Yang; Guo-Jian Shu; Yun Zhang; Fang Wu; Bi-Yu Ye; Xiang Hu; Yang, Wan-Zhang; Shu, Guo-Jian; Zhang, Yun; Wu, Fang; Ye, Bi-Yu; Hu, Xiang
- Abstract
<bold>Introduction: </bold>Herpes simplex virus is the most common cause of sporadic viral encephalitis. Cognitive impairments persist in most patients who survive herpes simplex virus-caused encephalitis after undergoing currently available treatments. This is the first report on the development of human cord blood-derived mononuclear cell transplantation as a new treatment intervention to improve the prognosis of sequelae of viral encephalitis.<bold>Case Presentation: </bold>An 11-year-old Han Chinese boy developed sequelae of viral encephalitis with cognitive, mental and motor impairments in the 8 months following routine treatments. Since receiving allogeneic cord blood-derived mononuclear cell transplantation combined with comprehensive rehabilitation therapies 7 years ago, the patient's health has significantly improved and remained stable.<bold>Conclusions: </bold>Human cord blood-derived mononuclear cell transplantation may be a potential therapeutic strategy for treating the neuropsychiatric and neurobehavioral sequelae of viral encephalitis.
- Subjects
VIRAL encephalitis; CELL transplantation; MILD cognitive impairment; NEUROPSYCHIATRY
- Publication
Journal of Medical Case Reports, 2013, Vol 7, Issue 1, p1
- ISSN
1752-1947
- Publication type
journal article
- DOI
10.1186/1752-1947-7-181