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- Title
Evaluation of Antioxidants Capacity of Non-Enzymatic Antioxidants and Its Effect in Glucose Level in Diabetic Patients.
- Authors
Mousa, Rana Fadhil
- Abstract
Background: Oxidative stress might participate in the pathophysiology of diabetes type 2. Systems of non-enzymatic antioxidants are made up of scavenging molecules that are formed endogenously.The Study Objective: This study’s aims were evaluation of the non-enzymatic antioxidants and their effect in levels of glucose among diabetic patients.Methodology: A total of eighty patients with DM type 2 and forty healthy persons (control) were enrolled within this study. Serum and plasma were obtained from collected blood samples. The Ferric Reducing Ability of Plasma (FRAP) method was used for detection of the total antioxidant capacity (TAC). Ellman’s method was used to determine the level of reduced glutathione. The serum CAT activity was detected by the technique explained by Sinha.Results: The findings revealed that, among diabetic groups, there was a significant elevation in glycosylated hemoglobin and glucose levels; HbA1c and FBG levels were significantly higher; MDA, NO, LPI, TAC and GSH showed significant greater values. The activity of SOD showed significantly greater mean value among the control group. Conclusion: The results suggest that antioxidants defense might be decreased in T2DM, as TAC levels were decreased. The increased levels of MDA, NO, LPI, TAC and GSH were associated with oxidative stress. Assessment of GSH could help in recognition of the extent of oxidative stress in diabetes as well as prevention and control of diabetic complications.
- Subjects
GLYCOSYLATED hemoglobin; OXIDANT status; PEOPLE with diabetes; OXIDATIVE stress; TYPE 2 diabetes; GLYCEMIC control
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2021, Vol 15, Issue 1, p2532
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v15i1.13781