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- Title
1141170685 Tumor-infiltrating lymphocytes contain higher proportion of FOXP3+ T lymphocytes from cervical cancer than that from cervical intraepithelial zneoplasm.
- Authors
Kuo, T. Y.; Ho, H. N.
- Abstract
Cervical cancer (CC) is preceded by well-defined changes in the epithelium known as cervical intraepithelial neoplasm (CIN). Our previous studies have revealed that the subpopulations and functions of tumor- infiltrating lymphocytes (TIL) from CC are altered. Dysfunction of the host immune system in cancer patients can be due to a number of reasons including the inhibitory functions of regulatory T (Treg) cells. FOXP3 has been shown to be a master control gene for the development and function of CD4+ CD25+ Treg cells. To characterize the functional role of Treg cells in progress of CC, we compared samples from four groups: CIN 2, CIN3, CC with and without tumor draining lymph node. By using the immunofluorescence staining and confocal-based image quantitative analysis in paraffin-embedded tissue sections, excess in the presence of FOXP3+ cells is observed from CC compared to that from CIN2/3. The significant difference of FOXP3+ cells expression level between CIN and CC indicate that the Treg might play an important role in the progression of CC.
- Subjects
CERVICAL cancer; EPITHELIUM; LYMPHOCYTES; T cells; LYMPH nodes
- Publication
American Journal of Reproductive Immunology, 2006, Vol 55, Issue 6, p396
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/j.1600-0897.2006.00383_15.x