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- Title
An Immunohistochemical Study of the Insulin-, Glucagon-, Orexin A- and Ghrelin- Immunoreactive Cells in the Endocrine Pancreas of Guinea Pig.
- Authors
YAMAN, Mine; BAYRAKDAR, Ali
- Abstract
The present study was conducted to clarify the regional distribution and relative frequency of endocrine cells secreting insulin, glucagon, orexin A (OXA) and ghrelin in the pancreatic islets of guinea pig, by specific immunohistochemical methods. In the pancreatic islets, most of insulin-IR cells were detected in the central region, partially in mantle region. Glucagon-IR cells were located in the periphery of the pancreatic islets. In addition, they had lower frequency in the central region. OXA and ghrelin- IR cells were identifed in central and peripheral regions of the pancreatic islets. Clearly, OXA-IR cells exhibited a characteristic distribution pattern resemble to those for the glucagon- IR cells. However, ghrelin immunoreactivity exhibited a characteristic distribution pattern different from that of insulin-immunoreactive cells. In conclusion, some species-dependent unique distributions characteristics of endocrine cells in the pancreatic islets were observed in the guinea pig.
- Subjects
IMMUNOHISTOCHEMISTRY; GUINEA pigs as laboratory animals; ISLANDS of Langerhans; INSULIN immunology; GLUCAGON; OREXINS; GHRELIN
- Publication
Kafkas Universitesi Veteriner Fakultesi Dergisi, 2013, Vol 19, Issue 1, p73
- ISSN
1300-6045
- Publication type
Article
- DOI
10.9775/kvfd.2012.7220